At the opening of the US stock market, the Dow Jones Industrial Average fell 0.33%, the S&P 500 fell 0.15%, and the Nasdaq Composite fell 0.13%. Novo Nordisk (NVO.N) plunged 15.65% after the company said its weight loss drug Cagrisema was less effective than Eli Lilly's Zepbound in clinical trials. Eli Lilly (LLY.N) opened 3.86% higher.